Genomics of apicomplexan parasites.
Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080Genomics of apicomplexan parasites.
Auteurs : Lakshmipuram Seshadri Swapna [Canada] ; John Parkinson [Canada]Source :
- Critical reviews in biochemistry and molecular biology [ 1549-7798 ] ; 2017.
Abstract
The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets. Comparative analyses of these datasets are beginning to identify the molecular innovations supporting both conserved processes mediating fundamental roles in parasite survival and persistence, as well as lineage-specific adaptations associated with divergent life-cycle strategies. The challenge is how best to exploit these data to derive insights into parasite virulence and identify those genes representing the most amenable targets. In this review, we outline genomic datasets currently available for apicomplexans and discuss biological insights that have emerged as a consequence of their analysis. Of particular interest are systems-based resources, focusing on areas of metabolism and host invasion that are opening up opportunities for discovering new therapeutic targets.
DOI: 10.1080/10409238.2017.1290043
PubMed: 28276701
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000000
- to stream PubMed, to step Curation: 000000
- to stream PubMed, to step Checkpoint: 000000
- to stream Ncbi, to step Merge: 002240
- to stream Ncbi, to step Curation: 002240
- to stream Ncbi, to step Checkpoint: 002240
- to stream Main, to step Merge: 000079
- to stream Main, to step Curation: 000079
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomics of apicomplexan parasites.</title><author><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name><affiliation wicri:level="1"><nlm:affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario </wicri:regionArea><wicri:noRegion>Ontario </wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario </wicri:regionArea><wicri:noRegion>Ontario </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28276701</idno><idno type="pmid">28276701</idno><idno type="doi">10.1080/10409238.2017.1290043</idno><idno type="wicri:Area/PubMed/Corpus">000000</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000000</idno><idno type="wicri:Area/PubMed/Curation">000000</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000000</idno><idno type="wicri:Area/PubMed/Checkpoint">000000</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000000</idno><idno type="wicri:Area/Ncbi/Merge">002240</idno><idno type="wicri:Area/Ncbi/Curation">002240</idno><idno type="wicri:Area/Ncbi/Checkpoint">002240</idno><idno type="wicri:Area/Main/Merge">000079</idno><idno type="wicri:Area/Main/Curation">000079</idno><idno type="wicri:Area/Main/Exploration">000079</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genomics of apicomplexan parasites.</title><author><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name><affiliation wicri:level="1"><nlm:affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario </wicri:regionArea><wicri:noRegion>Ontario </wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario </wicri:regionArea><wicri:noRegion>Ontario </wicri:noRegion></affiliation></author></analytic><series><title level="j">Critical reviews in biochemistry and molecular biology</title><idno type="eISSN">1549-7798</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets. Comparative analyses of these datasets are beginning to identify the molecular innovations supporting both conserved processes mediating fundamental roles in parasite survival and persistence, as well as lineage-specific adaptations associated with divergent life-cycle strategies. The challenge is how best to exploit these data to derive insights into parasite virulence and identify those genes representing the most amenable targets. In this review, we outline genomic datasets currently available for apicomplexans and discuss biological insights that have emerged as a consequence of their analysis. Of particular interest are systems-based resources, focusing on areas of metabolism and host invasion that are opening up opportunities for discovering new therapeutic targets.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name></noRegion><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000079 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000079 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28276701
|texte= Genomics of apicomplexan parasites.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28276701" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |